Multiscale Bone Remodelling with Spatial P Systems

Multiscale Bone Remodelling with Spatial P Systems

Many biological phenomena are inherently multiscale, i.e. they are characterized by interactions involving different spatial and temporal scales simultaneously. Though several approaches have been proposed to provide “multilayer” models, only Complex Automata, derived from Cellular Automata, naturally embed spatial information and realize multiscaling with well-established inter-scale integrati...

Multiscale Spatial Computational Systems Biology

This report documents the program and the outcomes of Dagstuhl Seminar 14481 “Multiscale Spatial Computational Systems Biology”. This seminar explored challenges arising from the need to model and analyse complex biological systems at multiple scales (spatial and temporal), which falls within the general remit of Computational Systems Biology. A distinguishing factor of the seminar was the mode...

Bone Structure and Bone Remodelling

Bone Remodelling in BioShape

Many biological phenomena are inherently multiscale, i.e. they are characterised by interactions involving different scales at the same time. This is the case of bone remodelling, where macroscopic behaviour (at organ and tissue scale) and microstructure (at cell scale) strongly influence each other. Consequently, several approaches have been defined to model such a process at different spatial...

What is the importance of multiphysical phenomena in bone remodelling signals expression? A multiscale perspective.

Cortical bone, constituting the outer shell of long bones, is continuously renewed by bone cells in response to daily stimuli. This process, known as bone remodelling, is essential for proper bone functioning in both physiological and pathological conditions. Classical bone remodelling models do not, or only implicitly do, take into account physico-chemical phenomena, focussing on the mechanose...